tag:blogger.com,1999:blog-37616971037544204142024-03-08T18:55:55.594+01:00Living with CFSLiving with Chronic Fatigue SyndromeZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-3761697103754420414.post-71208460000645426172015-03-31T16:38:00.000+02:002015-03-31T16:42:12.261+02:00Now the same scientists…<div class="MsoNormal" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 16.8pt; margin-top: 3pt;">
<span style="background-color: #444444;"><span style="font-size: 10pt;">...at the
Center for Infection and Immunity at Columbia University's Mailman School of
Public Health,</span><i style="font-size: 10pt;"> </i><span style="font-size: 10pt;">have also identified a
unique pattern of immune molecules in the cerebrospinal fluid of people with
myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) that provides
insights into the basis for cognitive dysfunction – frequently described by
patients as "brain fog" – as well as new hope for improvements in
diagnosis and treatment.</span></span></div>
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</span><b><span lang="EN-US" style="color: #e46c0a; font-size: 10.0pt; mso-ansi-language: EN-US; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-hansi-font-family: "Times New Roman"; mso-style-textfill-fill-alpha: 100.0%; mso-style-textfill-fill-color: #E46C0A; mso-style-textfill-fill-colortransforms: lumm=75000; mso-style-textfill-fill-themecolor: accent6; mso-themecolor: accent6; mso-themeshade: 191;"><a href="http://www.eurekalert.org/pub_releases/2015-03/cums-sfc032715.php"><span style="color: #e46c0a; mso-style-textfill-fill-alpha: 100.0%; mso-style-textfill-fill-color: #E46C0A; mso-style-textfill-fill-colortransforms: lumm=75000; mso-style-textfill-fill-themecolor: accent6; mso-themecolor: accent6; mso-themeshade: 191;">Scientists find
clues into cognitive dysfunction in chronic fatigue syndrome</span></a> </span></b><b><span lang="EN-US" style="font-size: 10.0pt; mso-ansi-language: EN-US; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-hansi-font-family: "Times New Roman";"><o:p></o:p></span></b></span></div>
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<span style="background-color: #444444;"><i><span lang="EN-US" style="font-size: 10.0pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV; mso-hansi-font-family: "Times New Roman";">EurekAlert! </span></i><span lang="EN-US" style="font-size: 10.0pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-hansi-font-family: "Times New Roman";"><o:p></o:p></span></span></div>
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<span style="background-color: #444444;"><span lang="EN-US" style="color: white; font-size: 10.0pt; mso-ansi-language: EN-US; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV; mso-hansi-font-family: "Times New Roman";"><br />
</span><a href="http://www.blogger.com/profile/10552303865803940754"><span lang="EN-US" style="color: #e1771e; font-size: 10.0pt; mso-ansi-language: EN-US; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV; mso-hansi-font-family: "Times New Roman"; text-decoration: none; text-underline: none;">ZenMaster</span></a></span><span lang="EN-US" style="color: white; font-family: "Times","serif"; font-size: 10.5pt; mso-ansi-language: EN-US; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV;"><o:p></o:p></span></div>
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ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-89698708603884839522015-02-28T03:35:00.003+01:002015-02-28T03:41:14.565+01:00Is this part of...<div class="MsoNormal" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 16.8pt; margin: 3pt 0cm 0.0001pt;">
<span style="background-color: #444444; font-family: Times, Times New Roman, serif; line-height: 19.2pt;">... the solution to what CFS
is? </span></div>
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<span style="background-color: #444444; font-family: Times, Times New Roman, serif;"><br /></span></div>
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<i><span lang="EN-US" style="background-color: #444444; font-family: Times, Times New Roman, serif;">“Researchers at the Center for Infection and Immunity
at Columbia University's Mailman School of Public Health identified distinct
immune changes in patients diagnosed with chronic fatigue syndrome, known
medically as myalgic encephalomyelitis (ME/CFS) or systemic exertion
intolerance disease. The findings could help improve diagnosis and identify
treatment options for the disabling disorder, in which symptoms range from
extreme fatigue and difficulty concentrating to headaches and muscle pain.” <o:p></o:p></span></i></div>
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<span style="background-color: #444444;"><span lang="EN-US" style="color: white; font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV;"><br />
</span><span style="font-family: Times, Times New Roman, serif;"><span lang="EN-US"><a href="http://www.eurekalert.org/pub_releases/2015-02/cums-sdr022315.php"><span style="color: #b45f06;"><b>Scientists discover
robust evidence that CFS is a biological illness</b></span></a> </span><span lang="EN-US" style="color: white; font-family: "Times","serif"; font-size: 10.5pt; mso-ansi-language: EN-US; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV;"><o:p></o:p></span></span></span></div>
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<span style="background-color: #444444; font-family: Times, Times New Roman, serif;"><i><span lang="EN-US" style="color: white; font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV;">EurekAlert! </span></i><span lang="EN-US" style="color: white; font-family: "Times","serif"; font-size: 10.5pt; mso-ansi-language: EN-US; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: SV;"><o:p></o:p></span></span></div>
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</span><br />
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<span style="font-family: Times, Times New Roman, serif;"><span lang="EN-US" style="background-color: #666666; color: white;"><br />
</span><a href="http://www.blogger.com/profile/10552303865803940754"><span style="color: #9fc5e8;"><b style="background-color: #444444;">ZenMaster</b></span></a></span><span lang="EN-US" style="background-color: #333333; color: white; font-family: Times, serif; font-size: 10.5pt;"><o:p></o:p></span></div>
ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-81177828496329436832013-09-22T11:16:00.001+02:002013-09-22T11:20:57.230+02:00Another virus... <span style="font-family: 'Times New Roman', serif; font-size: 10pt;">... suspect in CFS? </span><br />
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<br /></div>
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<i><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;">"Many experts believe that chronic fatigue syndrome (CFS) has
several root causes including some viruses. Now, lead scientists Shara Pantry,
Maria Medveczky and Peter Medveczky of the University of South Florida's
Morsani College of Medicine, along with the help of several collaborating
scientists and clinicians, have published an article in the Journal of
Medical Virology suggesting that a common virus, Human Herpesvirus 6
(HHV-6), is the possible cause of some CFS cases." <o:p></o:p></span></i></div>
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<span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;"><br />
</span><span style="font-family: "Times New Roman","serif"; font-size: 10.0pt;"><a href="http://www.sciencedaily.com/releases/2013/07/130726092427.htm"><span lang="EN-US">Chronic Fatigue Syndrome: Inherited
Virus Can Cause Cognitive Dysfunction and Fatigue</span></a></span><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;"><o:p></o:p></span></div>
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<i><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;">ScienceDaily <o:p></o:p></span></i></div>
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<span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;"><br />
<b>Reference: <o:p></o:p></b></span></div>
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<b><span lang="EN-US" style="color: #006600; font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-latin;">Persistent
human herpesvirus-6 infection in patients with an inherited form of the
virus </span></b></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;">Shara N. Pantry, Maria M. Medveczky, Jesse H.
Arbuckle, Janos Luka, Jose G. Montoya, Jianhong Hu, Rolf Renne, Daniel
Peterson, Joshua C. Pritchett, Dharam V. Ablashi, Peter G. Medveczky <o:p></o:p></span></div>
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<span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;">Journal of Medical Virology, 2013; DOI: </span><span style="font-family: "Times New Roman","serif"; font-size: 10.0pt;"><a href="http://dx.doi.org/10.1002/jmv.23685"><span lang="EN-US">10.1002/jmv.23685</span></a></span><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;"><o:p></o:p></span></div>
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<span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 10.0pt; mso-ansi-language: EN-US;"><br />
</span><span style="font-family: "Times New Roman","serif"; font-size: 10.0pt;"><a href="http://www.blogger.com/profile/10552303865803940754">ZenMaster</a><o:p></o:p></span></div>
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<span lang="EN-GB" style="background-color: #333333; color: #e1771e; font-family: Times, serif; font-size: 14px; line-height: 22.671875px; text-decoration: none;"><br /></span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-49943081689561584362013-07-24T23:53:00.000+02:002013-07-24T23:53:37.580+02:00Lactate biosensor could become…<div class="CellNEWS-mall">
<span style="font-family: Times, 'Times New Roman', serif;">… a simple test for CFS?</span></div>
<div class="CellNEWS-mall">
<br /></div>
<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody>
<tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/--OP2HYQ9mRo/UfBMXdwHDlI/AAAAAAAAMNU/h55ulkijuDo/s1600/Lactate_tattoo.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="120" src="http://1.bp.blogspot.com/--OP2HYQ9mRo/UfBMXdwHDlI/AAAAAAAAMNU/h55ulkijuDo/s200/Lactate_tattoo.jpg" width="200" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: left;"><span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><b><span lang="EN-GB">Credit</span></b><span lang="EN-GB">: American Chemical Society. </span></span></td></tr>
</tbody></table>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Saw this interesting article today.
Since lactic acid and lactate is the prime substances that makes muscle feel
exhausted and sour, may be this technique could become and easy way to test for
CSF. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<b><span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">First human tests of new biosensor
that warns when athletes are about to 'hit the wall'<o:p></o:p></span></span></b></div>
<div class="CellNEWS-mall">
<i><span style="font-family: Times, Times New Roman, serif;"><span lang="EN-GB">Wednesday, 24 July 2013</span></span></i></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">A new biosensor, applied to the human
skin like a temporary tattoo, can alert marathoners, competitive bikers and
other <i>"extreme"</i> athletes
that they're about to <i>"bonk,"</i>
or <i>"hit the wall,"</i>
scientists are reporting. The study, in ACS' journal Analytical Chemistry,
describes the first human tests of the sensor, which also could help soldiers
and others who engage in intense exercise — and their trainers — monitor
stamina and fitness.<o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Joseph Wang and colleagues explain that
the sensor monitors lactate, a form of lactic acid released in sweat. Lactate
forms when the muscles need more energy than the body can supply from the <i>"aerobic"</i> respiration that
suffices during mild exercise. The body shifts to <i>"anaerobic"</i> metabolism, producing lactic acid and
lactate. That helps for a while, but lactate builds up in the body, causing
extreme fatigue and the infamous <i>"bonking
out,"</i> where an athlete just cannot continue. Current methods of
measuring lactate are cumbersome, require blood samples or do not give instant
results. Wang's team sought to develop a better approach.<o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">They describe the first human tests of
a lactate sensor applied to the skin like a temporary tattoo that stays on and
flexes with body movements. Tests on 10 human volunteers showed that the sensor
accurately measured lactate levels in sweat during exercise. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><i><span lang="EN-US">"Such
skin-worn metabolite biosensors could lead to useful insights into physical
performance and overall physiological status, hence offering considerable
promise for diverse sport, military, and biomedical applications,"</span></i><span lang="EN-US"> say the scientists. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Future research will further correlate
sweat lactate levels with fitness, performance and blood lactate levels, Wang
added.<o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><b><span lang="EN-GB">Reference:
</span></b><span lang="EN-GB"><o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<b><span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Electrochemical Tattoo Biosensors
for Real-Time Noninvasive Lactate Monitoring in Human Perspiration<o:p></o:p></span></span></b></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Wenzhao Jia, Amay J. Bandodkar, Gabriela
Valdés-Ramírez, Joshua R. Windmiller, Zhanjun Yang, Julian
Ramírez, Garrett Chan, and Joseph Wang <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Anal. Chem., 2013, 85 (14),
pp 6553–6560, <a href="http://pubs.acs.org/doi/abs/10.1021/ac401573r">DOI: 10.1021/ac401573r</a><o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">.........
<o:p></o:p></span></span></div>
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<br /></div>
<br />
<div class="CellNEWS-mall">
<span lang="EN-US"><a href="http://www.blogger.com/profile/10552303865803940754"><span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">ZenMaster</span></span></a></span><span lang="EN-GB"> <o:p></o:p></span></div>
ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-34951718384015899882012-09-18T14:39:00.000+02:002012-09-18T14:39:22.084+02:00Finally a verdict… <br />
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;">… on XMRV and pMLV and CFS/ME.</span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><span lang="EN-US">In an extensive study funded by </span><span lang="EN-GB">National Institutes of Health and with many expert groups participating, the conclusion is that the original study by Dr. Mikovits that XMRV or similar viruses is a cause of CFS, is WRONG. No such links can be found. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">In a statement from Dr. Mikovits, the author of the Science paper wherein XMRV was first linked to CFS, she said: <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><i><span lang="EN-GB">"I greatly appreciated the opportunity to fully participate in this unprecedented study. Unprecedented because of the level of collaboration, the integrity of the investigators, and the commitment of the NIH to provide its considerable resources to the CFS community for this important study. Although I am disappointed that we found no association of XMRV/pMLV to CFS, the silver lining is that our 2009 Science report resulted in global awareness of this crippling disease and has sparked new interest in CFS research. I am dedicated to continuing to work with leaders in the field of pathogen discovery in the effort to determine the etiologic agent for CFS."</span></i><span lang="EN-GB"><o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><i><span lang="EN-GB">"Although the once promising XMRV and pMLV hypotheses have been excluded, the consequences of the early reports linking these viruses to disease are that new resources and investigators have been recruited to address the challenge of the CFS/ME",</span></i><span lang="EN-GB"> said W. Ian Lipkin, MD, director of the multi-site study and John Snow Professor of Epidemiology in the Mailman School of Public Health of Columbia University. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<i><span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">"We are confident that these investments will yield insights into the causes, prevention and treatment of CFS/ME."<o:p></o:p></span></span></i></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">Research on the causes of CFS/ME will continue, says Lipkin. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><i><span lang="EN-GB">"We've tested the XMRV/pMLV hypothesis and found it wanting,"</span></i><span lang="EN-GB"> he says. <o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">But, he says, <i>"we are not abandoning the patients. We are not abandoning the science. The controversy brought a new focus that will drive efforts to understand CFS/ME and lead to improvements in diagnosis, prevention and treatment of this syndrome."</i><o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<b><span lang="EN-GB"><span style="font-family: Times, Times New Roman, serif;">References: <o:p></o:p></span></span></b></div>
<div class="CellNEWS-mall">
<b><span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;"><a href="http://www.eurekalert.org/pub_releases/2012-09/cums-cfs091412.php">Chronic Fatigue Syndrome is Not Linked to Suspect Viruses</a> <o:p></o:p></span></span></b></div>
<div class="CellNEWS-mall">
<i><span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">Multi-site blinded study puts to rest the notion that these viruses cause the mysterious ailment<o:p></o:p></span></span></i></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><span lang="EN-US"><b><span style="color: #38761d;">EurekAlert!</span></b></span><span lang="EN-US"><b><span style="color: #38761d;"> </span></b>-</span><em><span lang="EN-US" style="background-color: white; background-position: initial initial; background-repeat: initial initial;"> </span></em><span lang="EN-US">Tuesday, 18 September 2012<o:p></o:p></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<b><span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;"><a href="http://www.eurekalert.org/pub_releases/2012-09/asfm-vnt091312.php">Viruses Not to Blame for Chronic Fatigue Syndrome After All</a> <o:p></o:p></span></span></b></div>
<div class="CellNEWS-mall">
<span style="font-family: Times, Times New Roman, serif;"><b><span lang="EN-US"><span style="color: #38761d;">EurekAlert!</span></span></b><span lang="EN-US"> -</span><em><span lang="EN-US" style="background-color: white; background-position: initial initial; background-repeat: initial initial;"> </span></em><span lang="EN-US">Tuesday, 18 September 2012<i> <o:p></o:p></i></span></span></div>
<div class="CellNEWS-mall">
<br /></div>
<div class="CellNEWS-mall">
<span lang="EN-US"><span style="font-family: Times, Times New Roman, serif;">ZenMaster</span><o:p></o:p></span></div>
ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-6456838684647588072010-08-23T23:52:00.002+02:002010-08-24T00:08:03.412+02:00A second study,…… published Monday by the Proceedings of the National Academy of Sciences, confirm the presence of XMRV and other MRV-related viruses in a high proportion of chronic fatigue syndrome patients. Scientists found gene sequences from several MRV-related viruses in blood cells from 32 out of 37 chronic-fatigue patients but only 3 of 44 healthy ones. <br />
<br />
<a href="http://www.nytimes.com/2010/08/24/health/research/24fatigue.html"><strong>Chronic Fatigue Linked to Virus Class</strong></a> <br />
<strong><span style="color: #38761d;">New York Times</span></strong> - 23 August 2010 <br />
When the journal Science published an attention-grabbing study last fall linking chronic fatigue syndrome to a recently discovered retrovirus, many experts remained skeptical — especially after four other studies found no such association. <br />
<br />
<strong>Reference: </strong><br />
<strong></strong><br />
<strong>Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors </strong><br />
Shyh-Ching Lo, Natalia Pripuzova, Bingjie Li, Anthony L. Komaroff, Guo-Chiuan Hung, Richard Wang, and Harvey J. Alter<br />
<strong><span style="color: #38761d;">PNAS</span></strong> published ahead of print August 23, 2010, <a href="http://www.pnas.org/content/early/2010/08/16/1006901107.abstract">doi:10.1073/pnas.1006901107</a> <br />
<br />
<br />
ZenMasterZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com2tag:blogger.com,1999:blog-3761697103754420414.post-46667871213155848592010-04-02T13:38:00.000+02:002010-04-02T13:38:10.747+02:00One more step…… towards a treatment of CFS? <br />
Scientists at University of Utah in Salt Lake City, Utah, and Emory University at Decatur, Georgia now report that several HIV drugs inhibit the replication of XMRV in cell cultures. <br />
<br />
Here is the original report: <br />
<strong>Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome </strong><br />
Ila R. Singh, John E. Gorzynski, Daria Drobysheva, Leda Bassit, Raymond F. Schinazi <br />
PLoS ONE 5(4): e9948. <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009948">doi:10.1371/journal.pone.0009948</a> <br />
<br />
They write the following: <br />
<strong>Principal Findings</strong><br />
Forty-five compounds, including twenty-eight drugs approved for use in humans, were evaluated against XMRV replication in vitro. We found that the retroviral integrase inhibitor, raltegravir, was potent and selective against XMRV at submicromolar concentrations, in MCF-7 and LNCaP cells, a breast cancer and prostate cancer cell line, respectively. Another integrase inhibitor, L-000870812, and two nucleoside reverse transcriptase inhibitors, zidovudine (ZDV), and tenofovir disoproxil fumarate (TDF) also inhibited XMRV replication. When combined, these drugs displayed mostly synergistic effects against this virus, suggesting that combination therapy may delay or prevent the selection of resistant viruses.<br />
<br />
You can also read more at: <br />
<strong><a href="http://www.eurekalert.org/pub_releases/2010-04/uouh-phd032910.php">Powerful HIV drugs inhibit retrovirus linked to prostate cancer, chronic fatigue syndrome</a></strong><br />
EurekAlert! 1-Apr-2010<br />
<strong><a href="http://www.eurekalert.org/pub_releases/2010-04/eu-adi033010.php">Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome</a></strong><br />
EurekAlert! 1-Apr-2010 <br />
<br />ZenMasterZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com1tag:blogger.com,1999:blog-3761697103754420414.post-13780062985197324542009-11-26T03:40:00.003+01:002009-11-26T03:45:39.671+01:00More news...<span style="font-family:times new roman;">... in NY Times: </span>
<p>
<a href="http://consults.blogs.nytimes.com/2009/11/24/expert-answers-on-chronic-fatigue-syndrome/"><span style="font-family:times new roman;"><strong>Expert Answers on Chronic Fatigue Syndrome</strong></span></a>
<span style="font-family:times new roman;">November 24, 2009</span>
<p>
<span style="font-family:times new roman;">Q&A on CFS. </span>
<p>
<span style="font-family:times new roman;">ZenMaster</span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-51906473766787005692009-10-09T15:45:00.001+02:002009-10-09T15:53:11.899+02:00Some interesting news…<strong>Chronic Fatigue Syndrome and Prostate Cancer Link to a Retrovirus
</strong>
<p>A new study published online by Science links chronic fatigue syndrome to a possibly contagious rodent retrovirus, XMRV or xenotropic murine leukaemia virus-related virus, which has also been implicated in an aggressive form of prostate cancer recently. Related work by the authors also suggests CFS might best be treated with AIDS drugs.
<p>
The XMRV virus is a retrovirus, like the HIV virus that causes AIDS. As with all viruses, a retrovirus copies its genetic code into the DNA of its host but uses RNA – a working form of DNA – instead of using DNA to do so.
<p>
Known formally as xenotropic murine leukaemia virus-related virus, XMRV has also been found in some prostate tumours and is also known to cause leukaemia and tumours in animals.
<p>
Researchers found the virus in the blood of 68 out of 101 chronic fatigue syndrome patients. The same virus showed up in only 8 of 218 healthy people, they reported on Thursday in the journal Science.
<p>
Judy Mikovits of the <a href="http://wpinstitute.org/xmrv/index.html">Whittemore Peterson Institute</a> in Nevada and colleagues at the National Cancer Institute and the Cleveland Clinic emphasized that the finding only shows a link between the virus and chronic fatigue syndrome, or CFS, and does not prove that the pathogen causes the disorder.
<p>
Much more study would be necessary to show a direct link, but Mikovits said the study offers hope that CFS sufferers might gain relief from a cocktail of drugs designed to fight AIDS, cancer and inflammation.
<p>
Previously a number of viruses, including herpes viruses, Enteroviruses, Coxsackie viruses and Epstein-Barr virus have been suggested as triggers for chronic fatigue syndrome. But these have only been found in a small minority of people with the disorder.
<p>
However, CFS researchers have long had their eyes on retroviruses. A number of the symptoms, including fatigue and cognitive dysfunction, can occur when the immune system is dealing with a viral infection, and the disease is often preceded by a flu-like illness. Although a number of retroviruses have been hypothesized to play a role in CFS, none has ever been confirmed.
<p>
About three years ago Robert Silverman, a biologist at the Cleveland Clinic Foundation in Ohio and a co-author of the new study, discovered a previously unknown retrovirus, XMRV, while searching for a pathogen that might contribute to prostate cancer. The retrovirus was very similar to MLV, a group of viruses that can cause cancer and neurological and immunological diseases in mice. Silverman found XMRV in a subset of prostate tumours, and more recent research found a stronger correlation between XMRV and aggressive prostate tumours.
<p>
Mikovits believes the association may be even stronger than the present work indicates. DNA sequencing only picks up active infections, she says, so she wants to study CFS exposure to the virus more broadly. In an unpublished investigation, she and her colleagues analyzed blood cells in about 330 CFS patients and found that more than 95% expressed antibodies to XMRV, whereas about 4% of healthy controls did.
<p>
<strong>Reference:
</p></strong><strong><p>Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome</strong>
<p>Vincent C. Lombardi, Francis W. Ruscetti, Jaydip Das Gupta, Max A. Pfost, Kathryn S. Hagen, Daniel L. Peterson, Sandra K. Ruscetti, Rachel K. Bagni, Cari Petrow-Sadowski, Bert Gold, Michael Dean, Robert H. Silverman, Judy A. Mikovits
<p>Science Published Online October 8, 2009, <a href="http://www.sciencemag.org/cgi/content/abstract/1179052v1">DOI: 10.1126/science.1179052</a>
<p>
ZenMaster
</p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-29001539676262716572009-01-14T05:34:00.002+01:002009-01-14T05:39:12.516+01:00Again…<span style="font-family:times new roman;">…I have not been writing for a long time. Some time ago, my father died after a short illness. He was 84, so I guess it was not completely unexpected, still difficult. However, around Christmas, I noticed that I anyhow had managed all that had happened around his illness, death and funeral surprisingly well – physically speaking. This betterment has continued now during January too, so maybe the extra weakness and pain from the hormone imbalances and pituitary surgery last spring finally is going away.
<p>I also now know that the MR brain scan in September showed a ‘clean’ pituitary! They didn’t see any residual tumour tissue on those pictures. Of course, in the end, there could be some few cells left, that slowly will continue to grow again, but for now everything looks fine.
<p>In the autumn, I was also referred to a new specialist, specialising in neuro-muscular diseases and genetic mitochondrial conditions that now are known from DNA sequencing investigations. I spent almost two hours going through my whole story, from 25 years ago until now, with him. Well, really my whole life story –medically speaking. He even asked about if I had noticed something already as a kid and when growing up. The result of this interview/discussion with him was that he was going to take some time and think about my condition and story, and if he could figure out something, he would come back. This was in early October.
<p>Well, now last week, I got an appointment for taking muscle biopsies. Exactly what he is going to check I don’t know, and I really don’t expect anything new to come out of this. But of course, it is good that someone is testing something new about CFS. Maybe there is something wrong with the energy producers in the muscle fibres – the mitochondria’s.
<p>I will have another, completely different test done too. My father died of a <a href="http://en.wikipedia.org/wiki/Abdominal_aortic_aneurysm"><span style="font-family:times new roman;">ruptured aortic aneurysm</span></a><span style="font-family:times new roman;">, and when I told my cardiologist about this at the yearly ultrasound check-up of my heart, he immediately referred me to the vessel specialists here at the hospital. The condition is much more common in male siblings of known patients, and furthermore they started general screenings of all men at 65 years here in Uppsala some two years ago. So the knowledge is present here. I only hope it has nothing to do with my known brain aneurysm, or the </span><a href="http://en.wikipedia.org/wiki/Hiatus_hernia"><span style="font-family:times new roman;">hiatal hernia</span></a> <span style="font-family:times new roman;">I have had for a long time now. It could be a generalized weakening of smooth muscle cells in these structures, but it could also be specialised disruptions at each site causing the different bulginess. No one knows the exact reason for aneurysms or hernias.
<p>ZenMaster</span></p>
</span><span style="font-family:times new roman;"></span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com5tag:blogger.com,1999:blog-3761697103754420414.post-29189618818575222012008-09-12T05:18:00.003+02:002008-09-12T05:34:21.077+02:00Today I had...<span style="font-family:times new roman;">... the first MR brain scan, again, after the surgery in March. Six months now since they were in and poking my pituitary. It's been some long summer months, mostly with heavy tiredness and pain in the muscles, but some short breaks for a couple of weeks when I felt better. Then again, tired, weak and in pain...
<p>
It has been disappointing; I had expected this summer would be better after so many years of weakness in my body. I try to convince myself (it only works from time to time... haha!) that it takes time for the body to adjust to the "normal" hormone levels. They are still exquisitely normal!!!
<p>
So, I expect the MR-scan will also show no residual tumour, at least not for now. It is strange how divergent our bodies can behave... I should be very well, but I feel like shit! </span></p>
<p><span style="font-family:times new roman;"><p></span></p>
<p><span style="font-family:times new roman;"><p></span></p>
<span style="font-family:times new roman;">ZenMaster</span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-36508548671908200812008-08-01T03:46:00.004+02:002008-08-01T03:53:12.947+02:00Could these drugs...<span style="font-family:times new roman;">... be something that would work for CFS?
<p>
<a href="http://www.hhmi.org/news/evans20080731.html"><strong>Researchers Identify Drugs that Enhance Exercise Endurance</strong></a>
<strong><span style="color:#009900;">HHMI News</span></strong> - July 31, 2008
<p>
<em>... </em><em>Researchers have identified two drugs that mimic many of the physiological effects of exercise. The drugs increase the ability of cells to burn fat and are the first compounds that have been shown to enhance exercise endurance.
<p>Both drugs can be given orally and work by genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue. In laboratory experiments, mice taking the drugs ran faster and longer than normal mice on treadmill tests. Animals that were given AICAR, one of the two drugs, ran 44 percent longer than untreated animals. The second compound, GW1516, had a more dramatic impact on endurance, but only when combined with exercise. </em></p><p><em>Ronald M. Evans, the Howard Hughes Medical Institute investigator who led the study, said drugs that mimic exercise could offer potent protection against obesity and related metabolic disorders. They could also help counter the effects of devastating muscle-wasting diseases like muscular dystrophy. Evans and his colleagues, who are at the Salk Institute for Biological Studies, published their findings on July 31, 2008, in an advance online publication in the journal Cell.
...</em>
</p><p>
ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com1tag:blogger.com,1999:blog-3761697103754420414.post-55578263910321579102008-08-01T03:44:00.001+02:002008-08-01T03:45:49.461+02:00There have been...<span style="font-family:times new roman;">... a few days of really hot summer weather here this and last week. The temperature has often been above 30 degrees Centigrade. THIS makes me feel great, at least less tiredness in muscles and less lactic acid-feeling in my legs! Everyone else (almost... hehe) complain about the hot weather, for me it is the <em>‘once-in-a-year’</em> time for some relaxing. I should already a long time ago, moved to a much warmer and sunny climate, I know!
<p>
ZenMaster </span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-88767722463447027942008-07-22T22:50:00.001+02:002008-07-22T22:53:32.437+02:00I’m still...<span style="font-family:times new roman;">... so extremely tired all the time. Today I was to an optician; I need new glasses for staring at this screen... hehe. The old one’s broke last week. After a long, almost an hour of checking my eyesight, she concluded that I should go back to an eye doctor before I get the new glasses. Some things were changed from earlier, and she could not (or would not) say if it was a result of the surgery, or ‘normal’ age-related changes. So now I have to find someone at the hospital – in the middle of their summer vacations, when many departments are closed – and try to pester them to give me a time as soon as possible! The Swedish healthcare doesn’t work particularly good during July and August – every doctor and nurse what their holiday then!
<p>
ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-21333005349788762772008-06-30T04:41:00.003+02:002008-06-30T04:51:36.460+02:00It's been a terrible month...<span style="font-family:times new roman;">... as you see, I have not posted in a long while! It's been a terrible month. Tired like hell in all my muscles, not sleepy, but tired and weak. Not so much pain this time. I was put on some cortisone again early in June, by my doctor, but it had no effect. Last week when I talked to her again, she could not understand why I was feeling so bad. So, 8 more tubes of blood on friday to the lab, to check a lot of the hormone levels again was the 'answer'! </span>
<span style="font-family:times new roman;"><p></span></p>
<span style="font-family:times new roman;">OK, ok, I do have CFS also, and that could be the explanation, but none of my doctors know anything about that, so I am just in limbo as usual. </span>
<p><span style="font-family:times new roman;"><p></span></p>
<span style="font-family:times new roman;">Well, I guess I should wait and see until these latest blood tests are done, maybe it is something wrong with some hormone system after all? Who knows... </span>
<p><span style="font-family:times new roman;"><p></span></p>
<span style="font-family:times new roman;">ZenMaster </span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com1tag:blogger.com,1999:blog-3761697103754420414.post-65426838025342335322008-05-31T08:02:00.002+02:002008-05-31T08:05:03.591+02:00Today...<span style="font-family:times new roman;">... NY Times has a series of articles about CFS. Not particularly informative, as usual, but still some attention to the problem!
<p>
<strong><a href="http://health.nytimes.com/ref/health/healthguide/esn-chronicfatigue-ess.html">Chronic Fatigue Syndrome No Longer Seen as ‘Yuppie Flu’</a></strong>
<strong><span style="color:#006600;">NY Times</span></strong> - Saturday, 31 May 2008
</span></p>
<span style="font-family:times new roman;">
ZenMaster </span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-33145361375234150872008-05-29T17:03:00.002+02:002008-05-29T17:10:11.376+02:00It's been some bad weeks again...<span style="font-family:times new roman;">... a couple of weeks ago, I stopped taking the cortisone I was administered after the surgery and removal of the pituitary tumour. While I was decreasing the dose, I started to feel extremely tired and weak. Now more than two weeks later, I still suffer from this extreme tiredness. I don't know why this happened, I though I would feel stronger when I could cut out the cortisone dose... hehe!
<p>
ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com1tag:blogger.com,1999:blog-3761697103754420414.post-5908833966396344402008-05-06T13:12:00.002+02:002008-05-06T13:16:39.404+02:00Seven different genetic types of CFS’ discovered...<span style="font-family:times new roman;">Geneticists from St George's Hospital, University of London have identified a biological basis for seven different subtypes of chronic fatigue syndrome.
<p>
The research findings are to be presented to a conference in Cambridge.
<p>
</span></p><strong><span style="font-family:times new roman;">Read more:
</span><a href="http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7378440.stm"><span style="font-family:times new roman;">Seven genetic types of ME' found</span></a></strong><a href="http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7378440.stm"><span style="font-family:times new roman;"> </span></a>
<p><span style="font-family:times new roman;"><strong><span style="color:#006600;">BBC</span></strong> - Monday, 5 May 2008 00:02 UK
<p><p>
ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-87605842045480288302008-04-08T06:10:00.002+02:002008-04-08T06:13:35.759+02:00A biological link between pain and fatigue?<span style="font-family:times new roman;">A recent University of Iowa study reveals a biological link between pain and fatigue and may help explain why more women than men are diagnosed with chronic pain and fatigue conditions like fibromyalgia and chronic fatigue syndrome.
</span><p><strong>Link:
</strong><a href="http://www.eurekalert.org/pub_releases/2008-04/uoi-uis040708.php"><span style="font-family:times new roman;">U. Iowa study finds biological link between pain and fatigue
</span></a></p>
<p>
<span style="font-family:times new roman;">ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-39971273594958057042008-04-08T06:02:00.002+02:002008-04-08T06:04:24.635+02:00I'm still...<span style="font-family:times new roman;">... recouperating from the surgery. It is getting better... slowly. </span>
<span style="font-family:times new roman;"><p></span></p>
<span style="font-family:times new roman;">ZenMaster </span>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-30450743018515571492008-03-12T17:27:00.002+01:002008-03-12T17:31:05.424+01:00I still feel like...<span style="font-family:times new roman;">...I have been smashed up on my nose and eye... hehe! The eye is running, and sometimes there is a little bleeding inside the nose. But on the whole, I have to say, it has gone pretty well. The worst thing: I had to shave off my moustache and beard, I have had for more than thirty years! My kids hardly recognized me; they had never seen me without it! Neither did I! I also have a lo of headache, so it makes me worried something is wrong.
</span><p>
<span style="font-family:times new roman;">But it was a ruff week, last week... But I guess it is just wait and see.
</span><p>
<span style="font-family:times new roman;">ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-46526521807990677962008-03-10T02:59:00.006+01:002008-12-09T09:38:56.920+01:00Finally I have had...<div align="left"><span style="font-family:times new roman;">...my transsphenoidal surgery last week, to remove the GH producing tumour in the pituitary.
<p><p>
Well, it was a little more complicated than just up through the nose, they also had to go in and open up from the outside of the nose, close to the tear duct on one side and the eye, so I was cut at two places during the procedure. Therefore it took six hours, instead of the regular 3 hours for the transsphenoidal surgery.
</p></div></span><div align="center"><hr /></div><div align="center">
</div><a href="http://1.bp.blogspot.com/_uwDUCYHxCxA/R9SWcCpuDuI/AAAAAAAABDE/jPespRadpg0/s1600-h/PICT0671ss.JPG"><img id="BLOGGER_PHOTO_ID_5175927280247901922" style="DISPLAY: block; MARGIN: 0px auto 10px; CURSOR: hand; TEXT-ALIGN: center" alt="" src="http://1.bp.blogspot.com/_uwDUCYHxCxA/R9SWcCpuDuI/AAAAAAAABDE/jPespRadpg0/s200/PICT0671ss.JPG" border="0" /> <p align="center"></a><span style="font-family:times new roman;"><em>This was a few days ago...
</p></em></span><hr /><span style="font-family:times new roman;">
Everything seem to have been going well, I could go home already on Friday. Tired and weak, of course, but somehow already feeling better in many parts of my body that have given so many symptoms and pain the last several years. Well, I have to wait and see. In a month’s time, the endocrinologists will make a lot of tests, to see what have happened with the pituitary function.
<p><p>
ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-36538517730227184002008-02-12T09:47:00.001+01:002008-04-08T06:06:07.158+02:00I wonder if...<span style="font-family:times new roman;">...this has anything to do with the extreme fatigue in CFS also!
<p>
ZenMaster
<p>
</span></p><a href="http://news.bbc.co.uk/2/hi/health/7238396.stm"><span style="font-family:times new roman;"><strong>Fatigue relief drug's heart hope</strong></span></a>
<p><span style="font-family:times new roman;">BBC News, UK - Feb. 11, 2008
</p></span><p>
Scientists are developing a drug which relieves fatigue after strenuous exercise - and it could benefit heart failure patients as well.
</p><span style="font-family:times new roman;"><p>
</span></p><a href="http://www.sciencedaily.com/releases/2008/02/080211172606.htm"><span style="font-family:times new roman;"><strong>Leaky Muscle Cells Lead To Fatigue</strong></span></a>
<p><span style="font-family:times new roman;">Science Daily - Feb. 11, 2008
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What do marathoners and heart failure patients have in common? More than you think according to new findings by physiologists at Columbia University Medical Center.
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</span></p><a href="http://www.nytimes.com/2008/02/12/health/research/12musc.html"><span style="font-family:times new roman;"><strong>Finding May Solve Riddle of Fatigue in Muscles</strong></span></a>
<p><span style="font-family:times new roman;">New York Times, United States - Feb. 11, 2008
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One of the great unanswered questions in physiology is why muscles get tired. The experience is universal, common to creatures that have muscles, but the answer has been elusive until now.
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<strong>References </p></strong><span style="font-family:times new roman;"><strong><p>
Remodeling of ryanodine receptor complex causes "leaky" channels:
</strong>A molecular mechanism for decreased exercise capacity
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Bellinger, A. M. et al. Proc. Natl Acad. Sci. USA <a href="http://www.pnas.org/cgi/content/abstract/0711074105v1">105, 2198-2202 (2008)</a>.
</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-49799914296179242872008-02-05T09:12:00.000+01:002008-02-05T09:15:44.612+01:00Still haven't got...<span style="font-family:times new roman;">... any exact time for the surgery. When I called the hospital last week the co-ordinator hadn't made any progress yet in the planning. So, I am waiting for the phone to call... this waiting is like hell!
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<span style="font-family:times new roman;">ZenMaster
</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com0tag:blogger.com,1999:blog-3761697103754420414.post-81320063690840794722008-01-31T17:27:00.000+01:002008-01-31T17:43:07.621+01:00Stopped taking the medication...<span style="font-family:times new roman;">This Monday, I stopped taking the medication for the pituitary tumour. It was the fifth attempt! I already feel much better, not so tired and no ache left in my legs anymore.
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I also had a new appointment with the neurosurgeon, and he again is prepared to perform the operation instead. But it is a sensitive procedure, especially how my tumour is situated; he is not sure he will reach it the usual way. And since it is the third time he have planned for surgery, I am not sure he will do it until it is done! Backing off a couple of day's before the operation is planned is extremely emotional draining.
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So, I just have to wait and see what happens next.
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ZenMaster</span></p>ZenMasterhttp://www.blogger.com/profile/10552303865803940754noreply@blogger.com1