Friday, 1 August 2008

Could these drugs...

... be something that would work for CFS?

Researchers Identify Drugs that Enhance Exercise Endurance HHMI News - July 31, 2008

... Researchers have identified two drugs that mimic many of the physiological effects of exercise. The drugs increase the ability of cells to burn fat and are the first compounds that have been shown to enhance exercise endurance.

Both drugs can be given orally and work by genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue. In laboratory experiments, mice taking the drugs ran faster and longer than normal mice on treadmill tests. Animals that were given AICAR, one of the two drugs, ran 44 percent longer than untreated animals. The second compound, GW1516, had a more dramatic impact on endurance, but only when combined with exercise.

Ronald M. Evans, the Howard Hughes Medical Institute investigator who led the study, said drugs that mimic exercise could offer potent protection against obesity and related metabolic disorders. They could also help counter the effects of devastating muscle-wasting diseases like muscular dystrophy. Evans and his colleagues, who are at the Salk Institute for Biological Studies, published their findings on July 31, 2008, in an advance online publication in the journal Cell. ...


There have been...

... a few days of really hot summer weather here this and last week. The temperature has often been above 30 degrees Centigrade. THIS makes me feel great, at least less tiredness in muscles and less lactic acid-feeling in my legs! Everyone else (almost... hehe) complain about the hot weather, for me it is the ‘once-in-a-year’ time for some relaxing. I should already a long time ago, moved to a much warmer and sunny climate, I know!